C1sc00556a 58..61
نویسندگان
چکیده
A new enantioselective a-oxidation of aldehydes has been accomplished using TEMPO and a synergistic combination of copper and organic catalysis. Expanding upon recently reported mechanistic studies, these mild catalytic conditions provide stable aldehyde products bearing a wide array of electronically and sterically diverse substructures. The utility of these oxidized products is highlighted by subsequent derivatization to a variety of common chiral synthons, without loss in enantiopurity.
منابع مشابه
Iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii Us008639070b2
USPC ................... 385/24; 385/14; 385/16; 385/18; 385/25; 385/34; 385/47; 385/129 (58) Field of ClassiTication Search USPC ........... 385/14, 16—18, 24, 25, 31, 33, 34, 47, 385/129—132 See application file for complete search history. (60) Provisional application No. 61/390, 837, filed on Oct. 7, 2010, provisional application No. 61/390, 876, filed on Oct. 7, 2010, provisional applicati...
متن کاملIron and nickel isotopic compositions of presolar SiC grains from supernovae
Approximately 1% of presolar SiC grains found in primitive meteorites condensed in the ejecta of Type II supernovae. To explain the isotopic signatures of these so-called X grains, material from different SN zones had to contribute to the mix from which the grains formed. We measured the Fe and Ni isotopic ratios of individual X grains with the NanoSIMS. Most grains have enhanced 57 Fe/ 56 Fe r...
متن کاملAn atypical catalytic mechanism involving three cysteines of thioredoxin.
Unlike other thioredoxins h characterized so far, a poplar thioredoxin of the h type, PtTrxh4, is reduced by glutathione and glutaredoxin (Grx) but not NADPH:thioredoxin reductase (NTR). PtTrxh4 contains three cysteines: one localized in an N-terminal extension (Cys(4)) and two (Cys(58) and Cys(61)) in the classical thioredoxin active site ((57)WCGPC(61)). The property of a mutant in which Cys(...
متن کاملFungal Bioterrorism Threat Gaining Public Interest , Yet Not Biggest Concern of Fungal Specialists , Survey Finds by Meredith Stone and John Scally
Fungal Bioterrorism ................................ 1-2 Find of Century: Additional Comments ...... 2 MSA Official Business From the President .................................. 3 From the Editor ....................................... 3 Mid-Year Executive Council Minutes .. 4-7 Managing Editor’s Mid-Year Report ....... 8 Council Email Express ............................. 9 Important Announce...
متن کاملDetection of N-, H-, and KRAS codons 12, 13, and 61 mutations with universal RAS primer multiplex PCR and N-, H-, and KRAS-specific primer extension.
OBJECTIVES Mutations of all three RAS genes, N-, H-, and KRAS, are identified mainly in codons 12, 13, and 61 of exons 2 and 3 in human cancers. DESIGN AND METHODS DNA samples were isolated from 58 oral cancer and 106 colorectal cancer patients. Multiplex amplification of codons 12 and 13 of exon 2 and codon 61 of exon 3 of three RAS genes using two pairs of universal primers for exons 2 and ...
متن کامل